{"id":40383,"date":"2025-06-24T12:01:14","date_gmt":"2025-06-24T05:01:14","guid":{"rendered":"https:\/\/saigonbiz.com.vn\/brightgene-trinh-bay-du-lieu-giai-doan-2-tich-cuc-cho-thuoc-kich-thich-kep-glp-1r-gipr-trong-quan-ly-can-nang-va-benh-tieu-duong-loai-2-cung-du-lieu-tien-lam-sang-cho-analog-amylin-moi-tai-hoi-nghi-k\/"},"modified":"2025-06-24T12:01:14","modified_gmt":"2025-06-24T05:01:14","slug":"brightgene-trinh-bay-du-lieu-giai-doan-2-tich-cuc-cho-thuoc-kich-thich-kep-glp-1r-gipr-trong-quan-ly-can-nang-va-benh-tieu-duong-loai-2-cung-du-lieu-tien-lam-sang-cho-analog-amylin-moi-tai-hoi-nghi-k","status":"publish","type":"post","link":"https:\/\/saigonbiz.com\/vn\/brightgene-trinh-bay-du-lieu-giai-doan-2-tich-cuc-cho-thuoc-kich-thich-kep-glp-1r-gipr-trong-quan-ly-can-nang-va-benh-tieu-duong-loai-2-cung-du-lieu-tien-lam-sang-cho-analog-amylin-moi-tai-hoi-nghi-k\/","title":{"rendered":"BrightGene Tr\u00ecnh B\u00e0y D\u1eef Li\u1ec7u Giai \u0110o\u1ea1n 2 T\u00edch C\u1ef1c Cho Thu\u1ed1c K\u00edch Th\u00edch K\u00e9p GLP-1R\/GIPR Trong Qu\u1ea3n L\u00fd C\u00e2n N\u1eb7ng V\u00e0 B\u1ec7nh Ti\u1ec3u \u0110\u01b0\u1eddng Lo\u1ea1i 2, C\u00f9ng D\u1eef Li\u1ec7u Ti\u1ec1n L\u00e2m S\u00e0ng Cho Analog Amylin M\u1edbi T\u1ea1i H\u1ed9i Ngh\u1ecb Khoa H\u1ecdc L\u1ea7n Th\u1ee9 85 C\u1ee7a Hi\u1ec7p H\u1ed9i Ti\u1ec3u \u0110\u01b0\u1eddng Hoa K\u1ef3"},"content":{"rendered":"<div>\n<ul type=\"disc\">\n<li> <i>D\u1eef li\u1ec7u Giai \u0111o\u1ea1n 2 nh\u1ea5n m\u1ea1nh ti\u1ec1m n\u0103ng h\u00e0ng \u0111\u1ea7u trong ph\u00e2n kh\u00fac c\u1ee7a thu\u1ed1c k\u00edch th\u00edch k\u00e9p GLP-1R\/GIPR BGM0504 trong qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng v\u00e0 gi\u1ea3m nguy c\u01a1 chuy\u1ec3n h\u00f3a \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 v\u00e0 nh\u1eefng ng\u01b0\u1eddi th\u1eeba c\u00e2n nh\u01b0ng kh\u00f4ng b\u00e9o ph\u00ec<\/i> <\/li>\n<li> <i>D\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng c\u1ee7a BGM1812 h\u1ed7 tr\u1ee3 vi\u1ec7c ph\u00e1t tri\u1ec3n ti\u1ebfp theo nh\u01b0 m\u1ed9t analog amylin th\u1ebf h\u1ec7 m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec\u00a0<\/i> <\/li>\n<\/ul>\n<p>T\u00d4 CH\u00c2U, TRUNG QU\u1ed0C, NG\u00c0Y 24 TH\u00c1NG 6 N\u0102M 2025 \/PRNewswire\/ &#8212; BrightGene Pharmaceutical Co., Ltd., m\u1ed9t c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m qu\u1ed1c t\u1ebf \u0111\u1ecbnh h\u01b0\u1edbng \u0111\u1ed5i m\u1edbi, \u0111\u00e3 tr\u00ecnh b\u00e0y d\u1eef li\u1ec7u t\u1eeb hai nghi\u00ean c\u1ee9u Giai \u0111o\u1ea1n 2 cho BGM0504, lo\u1ea1i thu\u1ed1c th\u1eed nghi\u1ec7m k\u00edch th\u00edch k\u00e9p nh\u1eafm v\u00e0o th\u1ee5 th\u1ec3 peptide gi\u1ed1ng glucagon-1 (GLP-1R) v\u00e0 th\u1ee5 th\u1ec3 polypeptide k\u00edch th\u00edch insulin ph\u1ee5 thu\u1ed9c glucose (GIPR), c\u00f9ng v\u1edbi d\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng cho analog amylin m\u1edbi, BGM1812, t\u1ea1i H\u1ed9i ngh\u1ecb Khoa h\u1ecdc l\u1ea7n th\u1ee9 85 c\u1ee7a Hi\u1ec7p h\u1ed9i Ti\u1ec3u \u0111\u01b0\u1eddng Hoa K\u1ef3 (ADA).<\/p>\n<p>K\u1ebft qu\u1ea3 t\u1eeb hai nghi\u00ean c\u1ee9u Giai \u0111o\u1ea1n 2 ri\u00eang bi\u1ec7t c\u1ee7a BGM0504 cho th\u1ea5y ti\u1ec1m n\u0103ng \u0111\u00e1ng k\u1ec3 trong qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng v\u00e0 gi\u1ea3m nguy c\u01a1 chuy\u1ec3n h\u00f3a \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 (bao g\u1ed3m \u01b0u th\u1ebf so v\u1edbi semaglutide), v\u00e0 \u1edf nh\u1eefng ng\u01b0\u1eddi th\u1eeba c\u00e2n ho\u1eb7c b\u00e9o ph\u00ec nh\u01b0ng kh\u00f4ng m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng. D\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng c\u1ee7a BGM1812 cho th\u1ea5y kh\u1ea3 n\u0103ng ho\u1ea1t h\u00f3a th\u1ee5 th\u1ec3 v\u01b0\u1ee3t tr\u1ed9i, gi\u1ea3m c\u00e2n m\u1ea1nh m\u1ebd v\u00e0 ti\u1ec1m n\u0103ng hi\u1ec7p \u0111\u1ed3ng v\u1edbi ho\u1ea1t h\u00f3a k\u00e9p GLP-1\/GIP, h\u1ed7 tr\u1ee3 ph\u00e1t tri\u1ec3n lo\u1ea1i thu\u1ed1c n\u00e0y nh\u01b0 m\u1ed9t analog amylin th\u1ebf h\u1ec7 m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec.<\/p>\n<p>&#8220;Nh\u1eefng d\u1eef li\u1ec7u Giai \u0111o\u1ea1n 2 n\u00e0y l\u00e0m n\u1ed5i b\u1eadt ti\u1ec1m n\u0103ng h\u00e0ng \u0111\u1ea7u trong ph\u00e2n kh\u00fac c\u1ee7a BGM0504 nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 v\u00e0 b\u00e9o ph\u00ec, bao g\u1ed3m kh\u1ea3 n\u0103ng v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi semaglutide v\u00e0 h\u1ed3 s\u01a1 an to\u00e0n m\u1ea1nh m\u1ebd, trong khi d\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng c\u1ee7a ch\u00fang t\u00f4i v\u1ec1 BGM1812 h\u1ed7 tr\u1ee3 vi\u1ec7c ph\u00e1t tri\u1ec3n li\u00ean t\u1ee5c nh\u01b0 m\u1ed9t analog amylin th\u1ebf h\u1ec7 m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec, nh\u1ea5n m\u1ea1nh th\u00eam tri\u1ec3n v\u1ecdng trong danh m\u1ee5c s\u1ea3n ph\u1ea9m c\u1ee7a ch\u00fang t\u00f4i,&#8221; \u00f4ng Jiandong Yuan, CEO c\u1ee7a BrightGene cho bi\u1ebft. &#8220;D\u1ef1a tr\u00ean chuy\u00ean m\u00f4n s\u00e2u r\u1ed9ng v\u1ec1 peptide v\u00e0 di s\u1ea3n v\u1eefng ch\u1eafc trong ph\u00e1t tri\u1ec3n thu\u1ed1c hi\u1ec7u qu\u1ea3 v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cao, BrightGene cam k\u1ebft th\u00fac \u0111\u1ea9y nhanh c\u00e1c li\u1ec7u ph\u00e1p \u0111\u1ed5i m\u1edbi nh\u1eb1m \u0111\u00e1p \u1ee9ng nhu c\u1ea7u ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n trong b\u1ec7nh chuy\u1ec3n h\u00f3a v\u00e0 c\u00e1c l\u0129nh v\u1ef1c \u0111i\u1ec1u tr\u1ecb quan tr\u1ecdng kh\u00e1c.&#8221;<\/p>\n<p> <b>Nghi\u00ean c\u1ee9u Giai \u0111o\u1ea1n 2 BGM0504 \u1edf b\u1ec7nh nh\u00e2n Ti\u1ec3u \u0111\u01b0\u1eddng Lo\u1ea1i 2<\/b> <\/p>\n<p>Nghi\u00ean c\u1ee9u \u0111a trung t\u00e2m, ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i (c\u00f3 \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c) v\u00e0 nh\u00e3n m\u1edf (c\u00f3 \u0111\u1ed1i ch\u1ee9ng t\u00edch c\u1ef1c v\u1edbi semaglutide) n\u00e0y \u0111\u00e1nh gi\u00e1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc, \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c ti\u00eam d\u01b0\u1edbi da h\u00e0ng tu\u1ea7n BGM0504 d\u1ef1a tr\u00ean ti\u00eau ch\u00ed ch\u00ednh l\u00e0 thay \u0111\u1ed5i HbA1c so v\u1edbi ban \u0111\u1ea7u t\u1ea1i Tu\u1ea7n th\u1ee9 12 s\u1eed d\u1ee5ng li\u1ec1u m\u1ee5c ti\u00eau, v\u00e0 nhi\u1ec1u ti\u00eau ch\u00ed ph\u1ee5 bao g\u1ed3m PPG-2 gi\u1edd, FPG, c\u00e2n n\u1eb7ng, HbA1c v\u00e0 t\u1ef7 l\u1ec7 \u0111\u1ea1t m\u1ee5c ti\u00eau k\u1ebft h\u1ee3p HbA1c\/c\u00e2n n\u1eb7ng, HOMA2-B, lipid m\u00e1u, huy\u1ebft \u00e1p t\u00e2m thu (SBP) v\u00e0 huy\u1ebft \u00e1p t\u00e2m tr\u01b0\u01a1ng (DBP).<\/p>\n<p>Nghi\u00ean c\u1ee9u \u0111\u00e3 tuy\u1ec3n ch\u1ecdn 67 ng\u01b0\u1eddi tham gia m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 trong \u0111\u1ed9 tu\u1ed5i t\u1eeb 18 \u0111\u1ebfn 65, trong \u0111\u00f3 64 ng\u01b0\u1eddi \u0111\u00e3 nh\u1eadn li\u1ec1u thu\u1ed1c sau khi ph\u00e2n nh\u00f3m ng\u1eabu nhi\u00ean, \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean th\u00e0nh n\u0103m nh\u00f3m: 5mg (n=13), 10mg (n=12), 15mg (n=13), nh\u00f3m \u0111\u1ed1i ch\u1ee9ng t\u00edch c\u1ef1c (semaglutide; n=16) ho\u1eb7c gi\u1ea3 d\u01b0\u1ee3c (n=13). Nh\u1eefng ng\u01b0\u1eddi tham gia bao g\u1ed3m ng\u01b0\u1eddi l\u1edbn c\u00f3 HbA1c ban \u0111\u1ea7u trong kho\u1ea3ng t\u1eeb 7,0% \u0111\u1ebfn 10,0% v\u00e0 ch\u1ec9 s\u1ed1 kh\u1ed1i c\u01a1 th\u1ec3 (BMI) t\u1eeb 19,5 \u0111\u1ebfn 35 kg\/m<sup>2<\/sup>.<\/p>\n<p>T\u1ea1i Tu\u1ea7n th\u1ee9 12 s\u1eed d\u1ee5ng li\u1ec1u m\u1ee5c ti\u00eau, \u0111i\u1ec1u tr\u1ecb v\u1edbi BGM0504 d\u1eabn \u0111\u1ebfn gi\u1ea3m HbA1c trong c\u1ea3 ba nh\u00f3m li\u1ec1u l\u01b0\u1ee3ng, v\u1edbi s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c v\u00e0 l\u1edbn h\u01a1n so v\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng semaglutide, bao g\u1ed3m -1,72% \u1edf nh\u00f3m 5mg, -1,94% \u1edf nh\u00f3m 10mg v\u00e0 -2,48% \u1edf nh\u00f3m 15mg, so v\u1edbi -1,43% c\u1ee7a semaglutide v\u00e0 -0,28% c\u1ee7a gi\u1ea3 d\u01b0\u1ee3c. K\u1ebft qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn trong nhi\u1ec1u ti\u00eau ch\u00ed ph\u1ee5, bao g\u1ed3m PPG-2 gi\u1edd, FPG, c\u00e2n n\u1eb7ng v\u00e0HbA1c v\u00e0 t\u1ef7 l\u1ec7 \u0111\u1ea1t m\u1ee5c ti\u00eau k\u1ebft h\u1ee3p HbA1c\/c\u00e2n n\u1eb7ng, trong khi c\u00e1c xu h\u01b0\u1edbng c\u1ea3i thi\u1ec7n kh\u00e1c nhau \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf HOMA2-B, lipid m\u00e1u, SBP v\u00e0 DBP. H\u1ea7u h\u1ebft c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 xu\u1ea5t hi\u1ec7n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb (TEAE) \u0111\u1ec1u \u1edf m\u1ee9c \u0111\u1ed9 1 ho\u1eb7c 2 trong giai \u0111o\u1ea1n ch\u1ec9nh li\u1ec1u nhanh v\u00e0 d\u1ea7n \u0111\u01b0\u1ee3c dung n\u1ea1p sau khi \u0111\u1ea1t \u0111\u1ebfn li\u1ec1u m\u1ee5c ti\u00eau. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n v\u00e0 ch\u01b0\u1edbng b\u1ee5ng; kh\u00f4ng ghi nh\u1eadn ph\u1ea3n \u1ee9ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft ho\u1eb7c c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 b\u1ea5t ng\u1edd kh\u00e1c.<\/p>\n<p> <b>Nghi\u00ean c\u1ee9u Giai \u0111o\u1ea1n 2 BGM0504 trong b\u00e9o ph\u00ec <\/b> <\/p>\n<p>Nghi\u00ean c\u1ee9u ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c n\u00e0y \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a BGM0504 \u1edf 120 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh Trung Qu\u1ed1c b\u1ecb b\u00e9o ph\u00ec trong qu\u00e1 tr\u00ecnh d\u00f9ng nhi\u1ec1u li\u1ec1u (ti\u00eam d\u01b0\u1edbi da). Nh\u1eefng ng\u01b0\u1eddi tham gia bao g\u1ed3m ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh c\u00f3 BMI \u2265 24kg\/m<sup>2<\/sup> (BMI trung b\u00ecnh t\u1ea1i th\u1eddi \u0111i\u1ec3m s\u00e0ng l\u1ecdc \u2265 27kg\/m<sup>2<\/sup>) k\u00e8m ti\u1ec1n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0\/ho\u1eb7c \u00edt nh\u1ea5t m\u1ed9t b\u1ec7nh l\u00fd \u0111i k\u00e8m li\u00ean quan \u0111\u1ebfn b\u00e9o ph\u00ec, ho\u1eb7c ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb b\u00e9o ph\u00ec (BMI \u2265 28kg\/m\u00b2, BMI trung b\u00ecnh t\u1ea1i th\u1eddi \u0111i\u1ec3m s\u00e0ng l\u1ecdc \u2265 30kg\/m\u00b2). Nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean v\u00e0o b\u1ed1n nh\u00f3m: 5 mg (n=30), 10 mg (n=30), 15 mg (n=30), ho\u1eb7c gi\u1ea3 d\u01b0\u1ee3c (n=30). Nghi\u00ean c\u1ee9u bao g\u1ed3m giai \u0111o\u1ea1n ch\u1ec9nh li\u1ec1u (2-6 tu\u1ea7n), \u0111i\u1ec1u tr\u1ecb trong 24 tu\u1ea7n v\u1edbi li\u1ec1u h\u00e0ng tu\u1ea7n, v\u00e0 theo d\u00f5i trong 2 tu\u1ea7n.<\/p>\n<p>K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u cho th\u1ea5y gi\u1ea3m v\u00f2ng eo t\u1eeb \u22128,0 cm \u0111\u1ebfn \u221212,98 cm (p &lt; 0,001), v\u00e0 gi\u1ea3m c\u00e2n \u0111\u00e1ng k\u1ec3 t\u1eeb -10,77% \u0111\u1ebfn -19,78% (trung b\u00ecnh LS, \u0111\u00e3 \u0111i\u1ec1u ch\u1ec9nh theo gi\u1ea3 d\u01b0\u1ee3c). K\u1ebft qu\u1ea3 c\u0169ng cho th\u1ea5y c\u1ea3i thi\u1ec7n huy\u1ebft \u00e1p t\u00e2m thu t\u1eeb \u221211,60 \u0111\u1ebfn \u221213,03 mmHg v\u00e0 huy\u1ebft \u00e1p t\u00e2m tr\u01b0\u01a1ng t\u1eeb \u22125,98 \u0111\u1ebfn \u22127,50 mmHg (p &lt; 0,05).<\/p>\n<p>C\u00e1c ch\u1ec9 s\u1ed1 ph\u1ee5 ti\u1ebfp t\u1ee5c c\u1ee7ng c\u1ed1 hi\u1ec7u qu\u1ea3 c\u1ee7a BGM0504 v\u00e0 t\u1ea5t c\u1ea3 c\u00e1c li\u1ec1u \u0111\u1ec1u \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t v\u1edbi c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn.<\/p>\n<p> <b>Nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng BGM1812<\/b> <\/p>\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng, BGM1812 cho th\u1ea5y ho\u1ea1t h\u00f3a th\u1ee5 th\u1ec3 m\u1ea1nh v\u1edbi ho\u1ea1t t\u00ednh k\u00edch th\u00edch t\u0103ng 1,8\u00d7 v\u00e0 2,2\u00d7 (EC50) t\u1ea1i c\u00e1c th\u1ee5 th\u1ec3 amylin v\u00e0 calcitonin, t\u01b0\u01a1ng \u1ee9ng, so v\u1edbi petrelintide. Ho\u1ea1t ch\u1ea5t n\u00e0y c\u0169ng cho th\u1ea5y gi\u1ea3m c\u00e2n ph\u1ee5 thu\u1ed9c li\u1ec1u trong kho\u1ea3ng li\u1ec1u 0,012 &#8211; 0,12 mg\/kg tr\u00ean m\u00f4 h\u00ecnh chu\u1ed9t b\u00e9o ph\u00ec do \u0103n u\u1ed1ng (DIO).<\/p>\n<p>T\u1ea1i li\u1ec1u 0,04 mg\/kg, BGM1812 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee9c gi\u1ea3m c\u00e2n l\u1edbn h\u01a1n so v\u1edbi petrelintide, m\u1ed9t s\u1ea3n ph\u1ea9m \u0111ang \u0111\u01b0\u1ee3c Zealand Pharma ph\u00e1t tri\u1ec3n. Ngo\u00e0i ra, BGM1812 duy tr\u00ec \u0111\u00e1ng k\u1ec3 kh\u1ed1i l\u01b0\u1ee3ng n\u1ea1c t\u01b0\u01a1ng \u0111\u1ed1i trong khi gi\u1ea3m kh\u1ed1i l\u01b0\u1ee3ng m\u1ee1 t\u01b0\u01a1ng \u0111\u1ed1i. B\u00ean c\u1ea1nh \u0111\u00f3, s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa BGM1812 v\u00e0 BGM0504 d\u1eabn \u0111\u1ebfn gi\u1ea3m c\u00e2n nhi\u1ec1u h\u01a1n v\u00e0 k\u00e9o d\u00e0i h\u01a1n so v\u1edbi c\u1ea3 semaglutide+cagrilintide ho\u1eb7c amycretin trong m\u00f4 h\u00ecnh chu\u1ed9t DIO.<\/p>\n<p> <b>V\u1ec1 BGM0504<\/b> <\/p>\n<p>Thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft d\u1ea1ng peptid BGM0504 l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch k\u00e9p c\u1ee7a c\u00e1c th\u1ee5 th\u1ec3 GLP-1 (glucagon-like peptide 1) v\u00e0 GIP (glucose-dependent insulinotropic polypeptide), \u0111\u01b0\u1ee3c BrightGene ph\u00e1t tri\u1ec3n \u0111\u1ed9c l\u1eadp. BGM0504 c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u00e1c con \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u c\u1ee7a GIP v\u00e0 GLP-1, t\u1ea1o ra c\u00e1c hi\u1ec7u \u1ee9ng sinh h\u1ecdc nh\u01b0 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, gi\u1ea3m c\u00e2n v\u00e0 \u0111i\u1ec1u tr\u1ecb vi\u00eam gan nhi\u1ec5m m\u1ee1 kh\u00f4ng do r\u01b0\u1ee3u (NASH), \u0111\u1ed3ng th\u1eddi cho th\u1ea5y ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u b\u1ec7nh chuy\u1ec3n h\u00f3a. Hi\u1ec7n BGM0504 \u0111ang trong giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3 t\u1ea1i Trung Qu\u1ed1c \u0111\u1ec3 qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng v\u00e0 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2, \u0111\u1ed3ng th\u1eddi \u0111\u00e3 ho\u00e0n t\u1ea5t nghi\u00ean c\u1ee9u giai \u0111o\u1ea1n 1 t\u1ea1i M\u1ef9 cho ch\u1ec9 \u0111\u1ecbnh qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng. T\u00ednh \u0111\u1ebfn nay, BGM0504 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u tr\u00ean h\u01a1n 1.000 b\u1ec7nh nh\u00e2n v\u00e0 cho th\u1ea5y hi\u1ec7u qu\u1ea3 v\u01b0\u1ee3t tr\u1ed9i c\u00f9ng h\u1ed3 s\u01a1 an to\u00e0n m\u1ea1nh m\u1ebd.<\/p>\n<p> <b>V\u1ec1 BGM1812<\/b> <\/p>\n<p>BGM1812 l\u00e0 m\u1ed9t analog amylin m\u1edbi, \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf th\u00f4ng qua t\u1ed1i \u01b0u h\u00f3a s\u1eed d\u1ee5ng AI\/ML nh\u1eb1m t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh k\u00edch th\u00edch v\u00e0 \u0111\u1eb7c t\u00ednh c\u00f4ng th\u1ee9c. L\u00e0 m\u1ed9t lo\u1ea1i amylin m\u1ea1nh v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i \u0111\u1eb7c bi\u1ec7t, BGM1812 c\u00f3 ti\u1ec1m n\u0103ng tr\u1edf th\u00e0nh vi\u00ean thu\u1ed1c u\u1ed1ng d\u00f9ng h\u00e0ng tu\u1ea7n.<\/p>\n<p> <b>V\u1ec1 BrightGene <br \/><\/b>BrightGene l\u00e0 m\u1ed9t c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m qu\u1ed1c t\u1ebf \u0111\u1ecbnh h\u01b0\u1edbng \u0111\u1ed5i m\u1edbi, ni\u00eam y\u1ebft tr\u00ean S\u1edf giao d\u1ecbch ch\u1ee9ng kho\u00e1n Th\u01b0\u1ee3ng H\u1ea3i, chuy\u00ean ph\u00e1t tri\u1ec3n v\u00e0 s\u1ea3n xu\u1ea5t c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u1ea5t l\u01b0\u1ee3ng cao \u0111\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u ch\u01b0a \u0111\u01b0\u1ee3c th\u1ecfa m\u00e3n c\u1ee7a b\u1ec7nh nh\u00e2n. \u0110\u01b0\u1ee3c th\u00e0nh l\u1eadp v\u00e0o n\u0103m 2001, BrightGene \u0111\u00e3 ph\u00e1t tri\u1ec3n t\u1eeb m\u1ed9t nh\u00e0 l\u00e3nh \u0111\u1ea1o to\u00e0n c\u1ea7u trong l\u0129nh v\u1ef1c bi\u1ec7t d\u01b0\u1ee3c v\u00e0 sinh ph\u1ea9m t\u01b0\u01a1ng t\u1ef1 c\u00f3 r\u00e0o c\u1ea3n cao tr\u1edf th\u00e0nh nh\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb chuy\u1ec3n h\u00f3a v\u00e0 h\u00f4 h\u1ea5p ti\u00ean ti\u1ebfn. L\u00e0 m\u1ed9t \u0111\u01a1n v\u1ecb d\u1eabn \u0111\u1ea7u trong l\u0129nh v\u1ef1c h\u00f3a h\u1ecdc ph\u1ee9c t\u1ea1p v\u00e0 li\u00ean h\u1ee3p, BrightGene s\u1edf h\u1eefu c\u00e1c n\u1ec1n t\u1ea3ng ti\u00ean ti\u1ebfn \u0111\u1ed9c quy\u1ec1n trong l\u0129nh v\u1ef1c peptid, siRNA, nanobody, c\u0169ng nh\u01b0 c\u00e1c c\u00f4ng th\u1ee9c ti\u00ean ti\u1ebfn, v\u00e0 c\u00f3 272 b\u1eb1ng s\u00e1ng ch\u1ebf. C\u00f4ng ty v\u1eabn l\u00e0 nh\u00e0 cung c\u1ea5p to\u00e0n c\u1ea7u cho 15 API v\u00e0 2 s\u1ea3n ph\u1ea9m thu\u1ed1c t\u1ea1i M\u1ef9 v\u00e0 EU. Tr\u1ee5 s\u1edf ch\u00ednh c\u1ee7a BrightGene \u0111\u1eb7t t\u1ea1i Trung Qu\u1ed1c. Th\u00f4ng tin th\u00eam c\u00f3 th\u1ec3 t\u00ecm th\u1ea5y t\u1ea1i <a href=\"https:\/\/www.bright-gene.com\/\" target=\"_blank\" rel=\"nofollow noopener\" style=\"color: #0000FF\">https:\/\/www.bright-gene.com\/<\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>D\u1eef li\u1ec7u Giai \u0111o\u1ea1n 2 nh\u1ea5n m\u1ea1nh ti\u1ec1m n\u0103ng h\u00e0ng \u0111\u1ea7u trong ph\u00e2n kh\u00fac c\u1ee7a thu\u1ed1c k\u00edch th\u00edch k\u00e9p GLP-1R\/GIPR BGM0504 trong qu\u1ea3n l\u00fd c\u00e2n n\u1eb7ng v\u00e0 gi\u1ea3m nguy c\u01a1 chuy\u1ec3n h\u00f3a \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 v\u00e0 nh\u1eefng ng\u01b0\u1eddi th\u1eeba c\u00e2n nh\u01b0ng kh\u00f4ng b\u00e9o ph\u00ec D\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng c\u1ee7a BGM1812 [&#8230;]\n","protected":false},"author":2604,"featured_media":50415,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[2293],"tags":[],"class_list":["post-40383","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>BrightGene Tr\u00ecnh B\u00e0y D\u1eef Li\u1ec7u Giai \u0110o\u1ea1n 2 T\u00edch C\u1ef1c Cho Thu\u1ed1c K\u00edch Th\u00edch K\u00e9p GLP-1R\/GIPR Trong Qu\u1ea3n L\u00fd C\u00e2n N\u1eb7ng V\u00e0 B\u1ec7nh Ti\u1ec3u \u0110\u01b0\u1eddng Lo\u1ea1i 2, C\u00f9ng D\u1eef Li\u1ec7u Ti\u1ec1n L\u00e2m S\u00e0ng Cho Analog Amylin M\u1edbi T\u1ea1i H\u1ed9i Ngh\u1ecb Khoa H\u1ecdc L\u1ea7n Th\u1ee9 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