{"id":35455,"date":"2024-10-21T12:04:54","date_gmt":"2024-10-21T05:04:54","guid":{"rendered":"https:\/\/saigonbiz.com.vn\/benh-vien-chang-gung-memorial-ra-mat-lieu-phap-te-bao-ngon-hai-dang-dem-lai-tia-sang-hy-vong-trong-linh-vuc-dieu-tri-ung-thu\/"},"modified":"2024-10-21T12:04:54","modified_gmt":"2024-10-21T05:04:54","slug":"benh-vien-chang-gung-memorial-ra-mat-lieu-phap-te-bao-ngon-hai-dang-dem-lai-tia-sang-hy-vong-trong-linh-vuc-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/saigonbiz.com\/vn\/benh-vien-chang-gung-memorial-ra-mat-lieu-phap-te-bao-ngon-hai-dang-dem-lai-tia-sang-hy-vong-trong-linh-vuc-dieu-tri-ung-thu\/","title":{"rendered":"B\u1ec7nh vi\u1ec7n Chang Gung Memorial ra m\u1eaft li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o: Ng\u1ecdn h\u1ea3i \u0111\u0103ng \u0111em l\u1ea1i tia s\u00e1ng hy v\u1ecdng trong l\u0129nh v\u1ef1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0"},"content":{"rendered":"<div>\n<p><i>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o \u0111ang n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t l\u0129nh v\u1ef1c ti\u00ean phong trong qu\u00e1 tr\u00ecnh \u0111\u1ed5i m\u1edbi y h\u1ecdc <\/i><\/p>\n<p>TAOYUAN, <span class=\"xn-chron\">21\/10\/2024<\/span> \/PRNewswire\/ &#8212; Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn mang t\u00ednh c\u00e1ch m\u1ea1ng. Khi s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p n\u00e0y, c\u00e1c t\u1ebf b\u00e0o s\u1ebd \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u00ean ngo\u00e0i v\u00e0 sau \u0111\u00f3 \u0111\u01b0a tr\u1edf l\u1ea1i b\u00ean trong c\u01a1 th\u1ec3 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ng\u0103n ng\u1eeba c\u00e1c lo\u1ea1i b\u1ec7nh t\u1eadt. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb r\u1ea5t h\u1ee9a h\u1eb9n trong l\u0129nh v\u1ef1c y t\u1ebf. B\u1ec7nh vi\u1ec7n <span class=\"xn-person\">Chang Gung<\/span> Memorial \u1edf \u0110\u00e0i Loan l\u00e0 b\u1ec7nh vi\u1ec7n \u0111i \u0111\u1ea7u trong vi\u1ec7c \u00e1p d\u1ee5ng li\u1ec7u ph\u00e1p ho\u00e0n to\u00e0n m\u1edbi n\u00e0y khi m\u00e0 v\u00e0o n\u0103m 2018, b\u1ec7nh vi\u1ec7n n\u00e0y \u0111\u00e3 th\u00e0nh l\u1eadp ph\u00f2ng th\u00ed nghi\u1ec7m Th\u1ef1c h\u00e0nh M\u00f4 t\u1ed1t (GTP) v\u1edbi s\u00e1u ph\u00f2ng x\u1eed l\u00fd t\u1ebf b\u00e0o \u0111\u1ea1t chu\u1ea9n PICS\/GMP qu\u1ed1c t\u1ebf. B\u1ec7nh vi\u1ec7n <span class=\"xn-person\">Chang Gung<\/span> Memorial \u0111\u00e3 t\u00edch c\u1ef1c h\u1ed7 tr\u1ee3 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch v\u00e0 t\u1ebf b\u00e0o y h\u1ecdc t\u00e1i t\u1ea1o kh\u00e1c nhau, v\u1edbi Khoa Y h\u1ecdc X\u00e9t nghi\u1ec7m l\u00e0 \u0111\u01a1n v\u1ecb \u0111\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn b\u1edfi Cao \u0111\u1eb3ng B\u1ec7nh h\u1ecdc Hoa K\u1ef3 (CAP) v\u00e0 l\u00e0 \u0111\u01a1n v\u1ecb ch\u1ecbu tr\u00e1ch nhi\u1ec7m ban h\u00e0nh b\u00e1o c\u00e1o ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng cho c\u00e1c quy tr\u00ecnh s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"> <a href=\"https:\/\/mma.prnasia.com\/media2\/2533150\/Chang_Gung_Memorial_Hospital_Linkou.html\" target=\"_blank\" rel=\"nofollow noopener\"> <img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2533150\/Chang_Gung_Memorial_Hospital_Linkou.jpg?p=medium600\" title=\"Chang Gung Memorial Hospital utilizes synthetic cancer cell antigens to train patients' immune cells to recognize and fight cancer cells. After multiplying, these immune cells are reintroduced into the body to eliminate cancer cells, all while using chemotherapy and radiotherapy to improve treatment outcomes. (Photo courtesy of Chang Gung Memorial Hospital)\" alt=\"Chang Gung Memorial Hospital utilizes synthetic cancer cell antigens to train patients' immune cells to recognize and fight cancer cells. After multiplying, these immune cells are reintroduced into the body to eliminate cancer cells, all while using chemotherapy and radiotherapy to improve treatment outcomes. (Photo courtesy of Chang Gung Memorial Hospital)\"> <\/a> <br \/><span>Chang Gung Memorial Hospital utilizes synthetic cancer cell antigens to train patients&#8217; immune cells to recognize and fight cancer cells. After multiplying, these immune cells are reintroduced into the body to eliminate cancer cells, all while using chemotherapy and radiotherapy to improve treatment outcomes. (Photo courtesy of Chang Gung Memorial Hospital)<\/span><\/p>\n<\/p><\/div>\n<p><b>Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 th\u00e2n b\u1eb1ng t\u1ebf b\u00e0o dendritic t\u1ef1 th\u00e2n-cytokine (DC-CIK) <\/b><\/p>\n<p>Ti\u1ebfn s\u0129 <span class=\"xn-person\">Wei-Chen Lee<\/span>, Ph\u00f3 gi\u00e1m \u0111\u1ed1c B\u1ec7nh vi\u1ec7n <span class=\"xn-person\">Chang Gung<\/span> Memorial, Linkou, m\u1ed9t c\u01a1 s\u1edf h\u00e0ng \u0111\u1ea7u v\u1ec1 gh\u00e9p gan t\u1ea1i \u0110\u00e0i Loan, \u0111\u00e3 nghi\u00ean c\u1ee9u v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c t\u1ef1 th\u00e2n (DC) \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 gan t\u1eeb n\u0103m 1998. Li\u1ec7u ph\u00e1p c\u1ee7a \u00f4ng \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng ch\u00fa \u00fd, c\u1ee5 th\u1ec3 l\u00e0 sau khi \u00e1p d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y, kh\u00f4ng ghi nh\u1eadn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ea5t k\u00ec kh\u1ed1i u n\u00e0o kh\u00e1c v\u00e0 t\u1ef7 l\u1ec7 ki\u1ec3m so\u00e1t b\u1ec7nh \u0111\u1ea1t t\u1edbi 70-80%. Nh\u00f3m c\u1ee7a \u00f4ng hi\u1ec7n \u0111ang ti\u1ebfn h\u00e0nh nghi\u00ean c\u1ee9u v\u1ec1 v\u1eafc-xin \u0111i\u1ec1u tr\u1ecb ung th\u01b0, v\u1edbi m\u1ee5c ti\u00eau tri\u1ec3n khai \u0111i\u1ec1u tr\u1ecb ngay sau ph\u1eabu thu\u1eadt \u0111\u1ec3 ng\u0103n ng\u1eeba ung th\u01b0 t\u00e1i ph\u00e1t.<\/p>\n<p>Gi\u00e1o s\u01b0 <span class=\"xn-person\">John Yu<\/span> t\u1eeb Vi\u1ec7n Nghi\u00ean c\u1ee9u T\u1ebf b\u00e0o g\u1ed1c v\u00e0 Ung th\u01b0 Chuy\u1ec3n d\u1ecbch (ISCTCR) \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00f4ng ngh\u1ec7 m\u1edf r\u1ed9ng &#8220;apexNK&#8221; ba giai \u0111o\u1ea1n m\u1edbi cho t\u1ebf b\u00e0o s\u00e1t th\u1ee7 t\u1ef1 nhi\u00ean (NK). K\u1ebft h\u1ee3p v\u1edbi ph\u01b0\u01a1ng ph\u00e1p chuy\u1ec3n gen virus hi\u1ec7u qu\u1ea3 cao, c\u00f4ng ngh\u1ec7 n\u00e0y t\u1ea1o ra m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch CAR-NK ho\u00e0n to\u00e0n m\u1edbi, gi\u00fap kh\u1eafc ph\u1ee5c nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a li\u1ec7u ph\u00e1p CAR truy\u1ec1n th\u1ed1ng trong \u0111i\u1ec1u tr\u1ecb kh\u1ed1i u r\u1eafn. Gi\u00e1m \u0111\u1ed1c Shuen-Iu Hung t\u1eeb Ph\u00f2ng th\u00ed nghi\u1ec7m l\u00f5i v\u1ec1 v\u1eafc-xin ung th\u01b0 v\u00e0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u00e3 ho\u00e0n th\u00e0nh c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng Giai \u0111o\u1ea1n I v\u1edbi m\u1ee5c ti\u00eau nh\u1eafm v\u00e0o c\u00e1c t\u00e2n kh\u00e1ng nguy\u00ean kh\u1ed1i u \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c kh\u1ed1i u r\u1eafn, m\u1edf \u0111\u01b0\u1eddng cho c\u00e1c \u1ee9ng d\u1ee5ng trong t\u01b0\u01a1ng lai li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb c\u00e1c kh\u1ed1i u di c\u0103n v\u00e0 c\u00e1c kh\u1ed1i u c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng nhi\u1ec1u lo\u1ea1i thu\u1ed1c.<\/p>\n<p><b>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T: Thu\u1ed1c s\u1ed1ng, m\u1ed9t li\u1ec7u ph\u00e1p mang t\u00ednh c\u00e1ch m\u1ea1ng trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 <\/b><\/p>\n<p>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T, hay li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean kh\u1ea3m, l\u00e0 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch \u0111\u1ed9t ph\u00e1 k\u1ebft h\u1ee3p li\u1ec7u ph\u00e1p gen v\u00e0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o. \u0110\u01b0\u1ee3c m\u1ec7nh danh l\u00e0 &#8220;thu\u1ed1c s\u1ed1ng&#8221;, ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y s\u1ebd thay \u0111\u1ed5i t\u1ebf b\u00e0o T mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n v\u1ec1 m\u1eb7t di truy\u1ec1n, cho ph\u00e9p ch\u00fang nh\u1eafm m\u1ee5c ti\u00eau ch\u00ednh x\u00e1c v\u00e0 lo\u1ea1i b\u1ecf c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 c\u1ee5 th\u1ec3. Nh\u1eefng t\u1ebf b\u00e0o T \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh v\u00e0 nh\u00e2n b\u1ea3n n\u00e0y sau \u0111\u00f3 s\u1ebd \u0111\u01b0\u1ee3c \u0111\u01b0a tr\u1edf l\u1ea1i c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n. Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T \u0111\u00e3 ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u lymphoblastic c\u1ea5p t\u00ednh (ALL) v\u00e0 u lympho t\u1ebf b\u00e0o B l\u1edbn lan t\u1ecfa (DLBCL). Do \u0111\u00f3, li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) nhanh ch\u00f3ng ch\u1ea5p thu\u1eadn \u0111\u01b0a v\u00e0o s\u1eed d\u1ee5ng.<\/p>\n<p>Hai tr\u01b0\u1eddng h\u1ee3p \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 b\u1ea1n Huahua, 13 tu\u1ed5i v\u00e0 b\u1ea1n Baobao, 8 tu\u1ed5i, hai b\u1ea1n \u0111\u1ec1u l\u00e0 con trai. C\u1ea3 hai \u0111\u1ec1u \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc b\u1ec7nh ALL v\u00e0 sau \u0111\u00f3 ph\u00e1t tri\u1ec3n th\u00e0nh b\u1ec7nh t\u00e1i ph\u00e1t ngo\u00e0i t\u1ee7y, trong \u0111\u00f3 Huahua b\u1ecb ph\u00ec \u0111\u1ea1i tinh ho\u00e0n hai b\u00ean v\u00e0 Baobao b\u1ecb ph\u00ec \u0111\u1ea1i tinh ho\u00e0n b\u00ean ph\u1ea3i, k\u00e8m theo t\u00ecnh tr\u1ea1ng s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o ung th\u01b0 c\u00f2n l\u1ea1i gia t\u0103ng (MRD).<\/p>\n<p>Tr\u01b0\u1edbc nh\u1eefng ca b\u1ec7nh kh\u00f3 n\u00e0y, Ti\u1ebfn s\u0129 <span class=\"xn-person\">Shih-Hsiang Chen<\/span>, Ph\u00f3 Gi\u00e1m \u0111\u1ed1c <span class=\"xn-person\">Khoa Nhi<\/span> c\u1ee7a b\u1ec7nh vi\u1ec7n, l\u01b0u \u00fd r\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u truy\u1ec1n th\u1ed1ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00e1i ph\u00e1t ngo\u00e0i t\u1ee7y s\u1ebd kh\u00f4ng \u0111em l\u1ea1i k\u1ebft qu\u1ea3 kh\u1ea3 quan. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb t\u1ea1i ch\u1ed7 nh\u01b0 c\u1eaft b\u1ecf tinh ho\u00e0n ho\u1eb7c x\u1ea1 tr\u1ecb c\u0169ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn ch\u1ee9c n\u0103ng sinh s\u1ea3n c\u1ee7a b\u1ec7nh nhi. Sau khi th\u1ea3o lu\u1eadn k\u1ef9 l\u01b0\u1ee1ng v\u1edbi gia \u0111\u00ecnh b\u1ec7nh nh\u00e2n, quy\u1ebft \u0111\u1ecbnh \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u01b0a ra l\u00e0 ti\u1ebfn h\u00e0nh li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T. Sau khi \u0111i\u1ec1u tr\u1ecb, c\u1ea3 hai b\u1ec7nh nh\u00e2n ch\u1ec9 b\u1ecb s\u1ed1t nh\u1eb9, m\u1ec7t m\u1ecfi v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c xu\u1ea5t vi\u1ec7n sau kho\u1ea3ng hai tu\u1ea7n. Hai em v\u1eabn ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c ch\u0103m s\u00f3c v\u00e0 theo d\u00f5i ngo\u1ea1i tr\u00fa.<\/p>\n<p>Ti\u1ebfn s\u0129 Cheng-Hsun Chiu, \u0111\u1ed3ng th\u1eddi l\u00e0 Ph\u00f3 gi\u00e1m \u0111\u1ed1c b\u1ec7nh vi\u1ec7n, cho bi\u1ebft r\u1eb1ng nh\u1eefng ti\u1ebfn b\u1ed9 trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u00e3 l\u00e0m thay \u0111\u1ed5i ho\u00e0n to\u00e0n b\u1ee9c tranh c\u1ee7a ng\u00e0nh n\u00e0y, ph\u00e1t tri\u1ec3n t\u1eeb c\u00e1c ph\u01b0\u01a1ng ph\u00e1p x\u1ea1 tr\u1ecb v\u00e0 h\u00f3a tr\u1ecb truy\u1ec1n th\u1ed1ng sang c\u00e1c li\u1ec7u ph\u00e1p nh\u1eafm m\u1ee5c ti\u00eau, c\u1ea5y gh\u00e9p t\u1ee7y x\u01b0\u01a1ng v\u00e0 hi\u1ec7n nay l\u00e0 c\u00e1c li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o ti\u00ean phong nh\u01b0 DC-CIK v\u00e0 CAR-T. Nh\u00ecn v\u1ec1 t\u01b0\u01a1ng lai, s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch h\u1ee9a h\u1eb9n s\u1ebd mang \u0111\u1ebfn nhi\u1ec1u \u0111\u1ed9t ph\u00e1 c\u00f4ng ngh\u1ec7 h\u01a1n, mang l\u1ea1i cho b\u1ec7nh nh\u00e2n nhi\u1ec1u l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb h\u01a1n v\u00e0 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 c\u1ea3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb l\u1eabn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o \u0111ang n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t l\u0129nh v\u1ef1c ti\u00ean phong trong qu\u00e1 tr\u00ecnh \u0111\u1ed5i m\u1edbi y h\u1ecdc TAOYUAN, 21\/10\/2024 \/PRNewswire\/ &#8212; Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn mang t\u00ednh c\u00e1ch m\u1ea1ng. Khi s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p n\u00e0y, c\u00e1c t\u1ebf b\u00e0o s\u1ebd \u0111\u01b0\u1ee3c x\u1eed l\u00fd b\u00ean ngo\u00e0i v\u00e0 sau [&#8230;]\n","protected":false},"author":2604,"featured_media":50415,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[2293],"tags":[],"class_list":["post-35455","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>B\u1ec7nh vi\u1ec7n Chang Gung Memorial ra m\u1eaft li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o: Ng\u1ecdn h\u1ea3i \u0111\u0103ng \u0111em l\u1ea1i tia s\u00e1ng hy v\u1ecdng trong l\u0129nh v\u1ef1c \u0111i\u1ec1u tr\u1ecb ung 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