{"id":33567,"date":"2024-07-24T00:04:59","date_gmt":"2024-07-23T17:04:59","guid":{"rendered":"https:\/\/saigonbiz.com.vn\/nghien-cuu-cua-nature-tiet-lo-bgm0504-duoc-thiet-ke-nho-dong-hoc-hoc-phan-tu-va-ai-cho-thay-tiem-nang-vuot-troi\/"},"modified":"2024-07-24T00:04:59","modified_gmt":"2024-07-23T17:04:59","slug":"nghien-cuu-cua-nature-tiet-lo-bgm0504-duoc-thiet-ke-nho-dong-hoc-hoc-phan-tu-va-ai-cho-thay-tiem-nang-vuot-troi","status":"publish","type":"post","link":"https:\/\/saigonbiz.com\/vn\/nghien-cuu-cua-nature-tiet-lo-bgm0504-duoc-thiet-ke-nho-dong-hoc-hoc-phan-tu-va-ai-cho-thay-tiem-nang-vuot-troi\/","title":{"rendered":"Nghi\u00ean c\u1ee9u c\u1ee7a Nature ti\u1ebft l\u1ed9: BGM0504 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf nh\u1edd \u0111\u1ed9ng h\u1ecdc h\u1ecdc ph\u00e2n t\u1eed v\u00e0 AI cho th\u1ea5y ti\u1ec1m n\u0103ng v\u01b0\u1ee3t tr\u1ed9i"},"content":{"rendered":"<div>\n<p>TH\u01af\u1ee2NG H\u1ea2I, <span class=\"xn-chron\">23\/07\/2024<\/span> \/PRNewswire\/ &#8212; Chi\u1ebfn l\u01b0\u1ee3c thi\u1ebft k\u1ebf ph\u00e2n t\u1eed v\u00e0 k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m c\u1ee7a ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1\/GIP k\u00e9p c\u1ee7a Bright Gene, BGM0504, \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u1ef1c tuy\u1ebfn tr\u00ean Scientific Reports, m\u1ed9t t\u1ea1p ch\u00ed chuy\u00ean \u0111\u1ec1 c\u1ee7a Nature, v\u00e0o ng\u00e0y 19 th\u00e1ng 7 n\u0103m 2024. Bright Gene (M\u00e3 ch\u1ee9ng kho\u00e1n: 688166.SH) l\u00e0 m\u1ed9t c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m \u0111\u1ed5i m\u1edbi m\u1edbi n\u1ed5i tr\u00ean tr\u01b0\u1eddng qu\u1ed1c t\u1ebf, chuy\u00ean ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i d\u01b0\u1ee3c ph\u1ea9m t\u1ed1t nh\u1ea5t \u0111\u1ec3 c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe b\u1ec7nh nh\u00e2n tr\u00ean to\u00e0n c\u1ea7u.<\/p>\n<p>B\u00e0i vi\u1ebft c\u00f3 ti\u00eau \u0111\u1ec1 &#8220;T\u1ed1i \u01b0u h\u00f3a nh\u1edd \u0111\u1ed9ng h\u1ecdc ph\u00e2n t\u1eed c\u1ee7a BGM0504 gi\u00fap t\u0103ng c\u01b0\u1eddng k\u00edch th\u00edch hai th\u1ee5 th\u1ec3 \u0111\u1ec3 ch\u1ed1ng l\u1ea1i b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 b\u00e9o ph\u00ec&#8221;, tr\u00ecnh b\u00e0y nh\u1eefng ph\u00e1t hi\u1ec7n v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a BGM0504.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder9053\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2466289\/image_5031720_25221542.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2466289\/image_5031720_25221542.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>BGM0504, ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GIP v\u00e0 GLP-1 k\u00e9p \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a AI, ch\u1ee9ng t\u1ecf hi\u1ec7u qu\u1ea3 v\u01b0\u1ee3t tr\u1ed9i trong c\u1ea3 th\u00ed nghi\u1ec7m\u00a0<i>trong \u1ed1ng nghi\u1ec7m<\/i> v\u00e0 <i>tr\u00ean c\u01a1 th\u1ec3 s\u1ed1ng<\/i>. S\u1eed d\u1ee5ng m\u00f4 ph\u1ecfng m\u00e1y t\u00ednh do AI \u0111i\u1ec1u khi\u1ec3n, Bright Gene \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng s\u1ef1 t\u01b0\u01a1ng t\u00e1c t\u1ed1i \u01b0u gi\u1eefa d\u01b0 l\u01b0\u1ee3ng glutamate tr\u00ean c\u1ea3 GLP-1R v\u00e0 GIPR v\u00e0 d\u01b0 l\u01b0\u1ee3ng K20 c\u1ee7a ch\u1ea5t ch\u1ee7 v\u1eadn peptide mang l\u1ea1i ho\u1ea1t \u0111\u1ed9ng v\u01b0\u1ee3t tr\u1ed9i. Ph\u00e1t hi\u1ec7n v\u1ec1 s\u1ef1 t\u01b0\u01a1ng t\u00e1c n\u00e0y l\u00e0 m\u1ed9t ki\u1ebfn th\u1ee9c quan tr\u1ecdng m\u00e0 c\u00e1c nghi\u00ean c\u1ee9u cryo-EM ch\u01b0a l\u00e0m s\u00e1ng t\u1ecf \u0111\u01b0\u1ee3c. BGM0504 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 b\u1ea3o to\u00e0n nh\u00f3m amino t\u1ef1 do c\u1ee7a d\u01b0 l\u01b0\u1ee3ng K20 b\u1eb1ng c\u00e1ch chuy\u1ec3n \u0111i\u1ec3m acyl h\u00f3a sang v\u1ecb tr\u00ed 40 c\u1ee7a BGM0504. Thi\u1ebft k\u1ebf n\u00e0y gi\u00fap t\u0103ng g\u1ea5p 3 l\u1ea7n t\u00e1c d\u1ee5ng ch\u1ee7 v\u1eadn tr\u00ean GLP-1R v\u00e0 GIPR, v\u1edbi k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u01b0\u1ee3t tr\u1ed9i tr\u00ean c\u00e1c m\u1eabu th\u1eed chu\u1ed9t m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 b\u00e9o ph\u00ec.<\/p>\n<p><b>Gi\u1edbi thi\u1ec7u v\u1ec1 Bright Gene v\u00e0 BGM0504<\/b><\/p>\n<p>Bright Gene (M\u00e3 ch\u1ee9ng kho\u00e1n: 688166.SH) l\u00e0 m\u1ed9t c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m \u0111\u1ed5i m\u1edbi chuy\u00ean ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i d\u01b0\u1ee3c ph\u1ea9m t\u1ed1t nh\u1ea5t. C\u00f4ng ty t\u00edch h\u1ee3p API v\u00e0 c\u00f4ng th\u1ee9c, k\u1ebft h\u1ee3p thu\u1ed1c g\u1ed1c v\u00e0 thu\u1ed1c c\u1ea3i ti\u1ebfn \u0111\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u l\u00e2m s\u00e0ng to\u00e0n c\u1ea7u. BGM0504 l\u00e0 ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GIP\/GLP-1 k\u00e9p \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2, b\u00e9o ph\u00ec v\u00e0 NASH, hi\u1ec7n \u0111ang \u1edf giai \u0111o\u1ea1n cu\u1ed1i c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng Giai \u0111o\u1ea1n II.<\/p>\n<p><b>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/b><\/p>\n<p>Yuan, J., Liu, W., Jiang, X. v\u00e0 c\u1ed9ng s\u1ef1. T\u1ed1i \u01b0u h\u00f3a nh\u1edd \u0111\u1ed9ng h\u1ecdc ph\u00e2n t\u1eed c\u1ee7a BGM0504 gi\u00fap t\u0103ng c\u01b0\u1eddng k\u00edch th\u00edch hai th\u1ee5 th\u1ec3 \u0111\u1ec3 ch\u1ed1ng l\u1ea1i b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 b\u00e9o ph\u00ec. Sci Rep 14, 16680 (2024).\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41598-024-66998-8\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1038\/s41598-024-66998-8<\/a><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>TH\u01af\u1ee2NG H\u1ea2I, 23\/07\/2024 \/PRNewswire\/ &#8212; Chi\u1ebfn l\u01b0\u1ee3c thi\u1ebft k\u1ebf ph\u00e2n t\u1eed v\u00e0 k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m c\u1ee7a ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1\/GIP k\u00e9p c\u1ee7a Bright Gene, BGM0504, \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u1ef1c tuy\u1ebfn tr\u00ean Scientific Reports, m\u1ed9t t\u1ea1p ch\u00ed chuy\u00ean \u0111\u1ec1 c\u1ee7a Nature, v\u00e0o ng\u00e0y 19 th\u00e1ng 7 n\u0103m 2024. Bright Gene (M\u00e3 ch\u1ee9ng [&#8230;]\n","protected":false},"author":2604,"featured_media":47255,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[2293],"tags":[],"class_list":["post-33567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pr-newswire"],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.6 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Nghi\u00ean c\u1ee9u c\u1ee7a Nature ti\u1ebft l\u1ed9: BGM0504 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf nh\u1edd \u0111\u1ed9ng h\u1ecdc h\u1ecdc ph\u00e2n t\u1eed v\u00e0 AI cho th\u1ea5y ti\u1ec1m n\u0103ng v\u01b0\u1ee3t 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