{"id":14570,"date":"2022-07-14T17:57:00","date_gmt":"2022-07-14T10:57:00","guid":{"rendered":"https:\/\/www.prnasia.com\/asia-story\/archive\/3815940_VI15940_11"},"modified":"2026-03-25T11:23:18","modified_gmt":"2026-03-25T04:23:18","slug":"glenmark-pharmaceuticals-va-sanotize-thong-bao-bai-dang-da-duoc-binh-duyet-ve-thu-nghiem-lam-sang-giai-doan-3-tren-san-pham-xit-mui-oxit-nitric-moi-cua-sanotize-cho-covid-19-tren-tap-chi-lancet","status":"publish","type":"post","link":"https:\/\/saigonbiz.com\/vn\/glenmark-pharmaceuticals-va-sanotize-thong-bao-bai-dang-da-duoc-binh-duyet-ve-thu-nghiem-lam-sang-giai-doan-3-tren-san-pham-xit-mui-oxit-nitric-moi-cua-sanotize-cho-covid-19-tren-tap-chi-lancet\/","title":{"rendered":"Glenmark Pharmaceuticals v\u00e0 SaNOtize th\u00f4ng b\u00e1o b\u00e0i \u0111\u0103ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00ecnh duy\u1ec7t v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3 tr\u00ean s\u1ea3n ph\u1ea9m x\u1ecbt m\u0169i Oxit Nitric m\u1edbi c\u1ee7a SaNOtize cho COVID-19 tr\u00ean T\u1ea1p ch\u00ed Lancet"},"content":{"rendered":"
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MUMBAI<\/span>, \u1ea4n \u0110\u1ed9 v\u00e0 VANCOUVER, BC<\/span><\/span>, ng\u00e0y 14 th\u00e1ng 7 n\u0103m 2022<\/span> \/PRNewswire\/ —\u00a0Glenmark Pharmaceuticals Limited (Glenmark), m\u1ed9t c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m to\u00e0n c\u1ea7u, h\u01b0\u1edbng t\u1edbi \u0111\u1ed5i m\u1edbi v\u00e0 SaNOtize Research and Development Corp, h\u00f4m nay \u0111\u00e3 th\u00f4ng b\u00e1o r\u1eb1ng The Lancet Regional Health Southeast Asia (TLRHSEA) – <\/i>\u0111\u01b0\u1ee3c b\u00ecnh duy\u1ec7t v\u00e0 c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn trong c\u1ed9ng \u0111\u1ed3ng, \u0111\u00e3 c\u00f4ng b\u1ed1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3 cho k\u1ebft qu\u1ea3 th\u00e0nh c\u00f4ng khi nghi\u00ean c\u1ee9u s\u1ea3n ph\u1ea9m X\u1ecbt M\u0169i Oxit Nitric (Nitric Oxide Nasal Spray – NONS) c\u1ee7a SaNOtize v\u1edbi ti\u00eau \u0111\u1ec1: ‘SARS-CoV-2 t\u0103ng t\u1ed1c \u0111\u00e0o th\u1ea3i b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb x\u1ecbt m\u0169i oxit nitric m\u1edbi (NONS): M\u1ed9t th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean’.<\/p>\n

https:\/\/www.thelancet.com\/journals\/lansea\/article\/PIIS2772-3682(22)00046-4\/fulltext<\/a><\/p>\n

“Ch\u00fang t\u00f4i r\u1ea5t vui m\u1eebng khi \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n nghi\u00ean c\u1ee9u s\u1ea3n ph\u1ea9m X\u1ecbt M\u0169i Oxit Nitric m\u1edbi, t\u00e1c \u0111\u1ed9ng t\u00edch c\u1ef1c \u0111\u1ebfn cu\u1ed9c s\u1ed1ng c\u1ee7a m\u1ecdi ng\u01b0\u1eddi, tr\u00ean nh\u00f3m t\u1ea1p ch\u00ed The Lancet. Th\u1eed nghi\u1ec7m m\u00f9 \u0111\u00f4i v\u1eefng ch\u1eafc \u0111\u00e3 ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 v\u00e0 m\u1ee9c \u0111\u1ed9 an to\u00e0n \u0111\u00e1ng k\u1ec3 c\u1ee7a NONS. Li\u1ec7u ph\u00e1p n\u00e0y c\u00f3 ti\u1ec1m n\u0103ng quan tr\u1ecdng trong qu\u1ea3n l\u00fd COVID-19 v\u00ec d\u1ec5 s\u1eed d\u1ee5ng trong giai \u0111o\u1ea1n l\u00e2y lan cao c\u1ee7a \u0111\u1ea1i d\u1ecbch nh\u01b0 hi\u1ec7n t\u1ea1i”, Ti\u1ebfn s\u0129 Monika Tandon<\/span>, Ph\u00f3 ch\u1ee7 t\u1ecbch C\u1ea5p cao & Tr\u01b0\u1edfng ph\u00f2ng – Ph\u00e1t tri\u1ec3n L\u00e2m s\u00e0ng, Glenmark Pharmaceuticals Ltd.<\/i><\/b><\/p>\n

Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng b\u1ec7nh nh\u00e2n nh\u1eadn NONS \u0111\u00e3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ea3i l\u01b0\u1ee3ng vi-r\u00fat trong v\u00f2ng 24 gi\u1edd, hi\u1ec7u qu\u1ea3 n\u00e0y \u0111\u01b0\u1ee3c k\u00e9o d\u00e0i trong h\u01a1n b\u1ea3y ng\u00e0y \u0111i\u1ec1u tr\u1ecb. T\u1ea3i l\u01b0\u1ee3ng vi-r\u00fat \u0111\u00e3 gi\u1ea3m 93,7% trong v\u00f2ng 24 gi\u1edd v\u00e0 99% trong v\u00f2ng 48 gi\u1edd \u0111i\u1ec1u tr\u1ecb b\u1eb1ng NONS. M\u1ee9c \u0111\u1ed9 thay \u0111\u1ed5i trung b\u00ecnh so v\u1edbi ban \u0111\u1ea7u v\u1ec1 t\u1ea3i l\u01b0\u1ee3ng RNA c\u1ee7a vi-r\u00fat trong to\u00e0n b\u1ed9 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb l\u00e0 cao h\u01a1n v\u1ec1 m\u1eb7t th\u1ed1ng k\u00ea \u1edf nh\u00f3m NONS so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c. K\u1ebft qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf c\u1ea3 c\u00e1c nh\u00f3m \u0111\u00e3 ti\u00eam ch\u1ee7ng v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong c\u00e1c giai \u0111o\u1ea1n ch\u1ee7ng delta v\u00e0 omicron \u0111ang ho\u1ea1t \u0111\u1ed9ng m\u1ea1nh. C\u00e1c ti\u00eau ch\u00ed ph\u1ee5 quan tr\u1ecdng bao g\u1ed3m c\u1ea3i thi\u1ec7n l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1edfi Thang \u0111i\u1ec3m ti\u1ebfn tri\u1ec3n l\u00e2m s\u00e0ng c\u1ee7a WHO v\u00e0 m\u1ee9c \u0111\u1ed9 nhanh ch\u00f3ng trong ph\u1ee5c h\u1ed3i vi-r\u00fat h\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng NONS. Th\u1eddi gian trung b\u00ecnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb vi-r\u00fat l\u00e0 ba ng\u00e0y trong nh\u00f3m NONS v\u00e0 b\u1ea3y ng\u00e0y trong nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb (b\u1ed1n ng\u00e0y s\u1edbm h\u01a1n). \u0110\u00e1nh gi\u00e1 th\u0103m d\u00f2 v\u1ec1 t\u1ef7 l\u1ec7 nh\u1eefng ng\u01b0\u1eddi ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp c\u00f3 x\u00e9t nghi\u1ec7m COVID-19 d\u01b0\u01a1ng t\u00ednh ho\u1eb7c c\u00f3 tri\u1ec7u ch\u1ee9ng, g\u1ea7n nh\u01b0 kh\u00f4ng \u0111\u1ed5i \u1edf nh\u00f3m NONS trong khi t\u1ef7 l\u1ec7 n\u00e0y t\u0103ng l\u00ean \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n

“K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u Giai \u0111o\u1ea1n 3 \u1ee7ng h\u1ed9 m\u1ea1nh m\u1ebd t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a NONS trong \u0111i\u1ec1u tr\u1ecb COVID-19 v\u00e0 c\u00e1c bi\u1ebfn th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn”, Gilly Regev<\/span>, Ti\u1ebfn s\u0129, Nh\u00e0 \u0111\u1ed3ng s\u00e1ng l\u1eadp v\u00e0 Gi\u00e1m \u0111\u1ed1c \u0110i\u1ec1u h\u00e0nh SaNOtize cho bi\u1ebft. “<\/i><\/b>\u00a0Oxit nitric ng\u0103n ch\u1eb7n x\u00e2m nh\u1eadp v\u00e0o \u0111\u01b0\u1eddng m\u0169i, ti\u00eau di\u1ec7t vi-r\u00fat v\u00e0 ng\u0103n ch\u1eb7n vi-r\u00fat nh\u00e2n b\u1ea3n, \u0111\u00f3 l\u00e0 l\u00fd do t\u1ea1i sao t\u1ea3i l\u01b0\u1ee3ng vi-r\u00fat gi\u1ea3m nhanh ch\u00f3ng v\u1edbi NONS. T\u1ea3i l\u01b0\u1ee3ng vi-r\u00fat c\u00f3 li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e2y nhi\u1ec5m, d\u1eabn \u0111\u1ebfn s\u1ee9c kh\u1ecfe k\u00e9m h\u01a1n v\u00e0 c\u00e1c bi\u1ebfn ch\u1ee9ng t\u1eeb COVID k\u00e9o d\u00e0i. B\u1eb1ng ch\u1ee9ng cho th\u1ea5y NONS \u0111\u1ea1i di\u1ec7n cho m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1ng vi-r\u00fat hi\u1ec7u qu\u1ea3, \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t v\u00e0 r\u00fat ng\u1eafn th\u1eddi gian ho\u1ea1t \u0111\u1ed9ng c\u1ee7a COVID-19″.<\/i> <\/b><\/p>\n

Thi\u1ebft k\u1ebf nghi\u00ean c\u1ee9u<\/b><\/p>\n

Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi Glenmark tr\u00ean 306 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng nhi\u1ec5m COVID-19 c\u00f3 tri\u1ec7u ch\u1ee9ng nh\u1eb9 tr\u00ean 20 c\u01a1 s\u1edf l\u00e2m s\u00e0ng \u1edf \u1ea4n \u0110\u1ed9. Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i \u1edf giai \u0111o\u1ea1n 3 n\u00e0y \u0111\u00e3 \u0111\u00e1nh gi\u00e1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb 7 ng\u00e0y c\u1ee7a NONS c\u1ed9ng v\u1edbi ch\u0103m s\u00f3c ti\u00eau chu\u1ea9n so v\u1edbi x\u1ecbt m\u0169i gi\u1ea3 d\u01b0\u1ee3c c\u1ed9ng v\u1edbi ch\u0103m s\u00f3c ti\u00eau chu\u1ea9n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n COVID-19 c\u00f3 tri\u1ec7u ch\u1ee9ng. Ph\u01b0\u01a1ng ph\u00e1p \u0111o k\u1ebft qu\u1ea3 ch\u00ednh t\u1eeb vi\u1ec7c \u0111\u00e0o th\u1ea3i t\u0103ng t\u1ed1c RNA c\u1ee7a SARS-CoV-2 qua m\u0169i \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 c\u1ee7a NONS \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao (ch\u01b0a \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng, ho\u1eb7c 45 tu\u1ed5i, ho\u1eb7c c\u00f3 m\u1ed9t ho\u1eb7c nhi\u1ec1u b\u1ec7nh \u0111i k\u00e8m) sau b\u1ea3y ng\u00e0y \u0111i\u1ec1u tr\u1ecb. \u0110\u00e1nh gi\u00e1 th\u0103m d\u00f2 v\u1ec1 NONS trong vi\u1ec7c ng\u0103n ng\u1eeba l\u00e2y nhi\u1ec5m khi ti\u1ebfp x\u00fac tr\u1ef1c ti\u1ebfp v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n COVID-19 n\u00e0y c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1.<\/p>\n

Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb v\u1edbi NONS \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 dung n\u1ea1p t\u1ed1t v\u00ec v\u1eady mang l\u1ea1i l\u1ee3i th\u1ebf cho li\u1ec7u ph\u00e1p x\u1ecbt m\u0169i c\u1ee5c b\u1ed9. Kh\u00f4ng b\u1ec7nh nh\u00e2n n\u00e0o b\u00e1o c\u00e1o b\u1ea5t k\u1ef3 bi\u1ec3u hi\u1ec7n b\u1ea5t th\u01b0\u1eddng n\u00e0o \u1edf m\u1ee9c \u0111\u1ed9 trung b\u00ecnh ho\u1eb7c nghi\u00eam tr\u1ecdng. Kh\u00f4ng c\u00f3 thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 n\u00e0o v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng so v\u1edbi ban \u0111\u1ea7u \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong methemoglobin cho th\u1ea5y thi\u1ebfu oxit nitric to\u00e0n th\u00e2n khi x\u1ecbt m\u0169i. Ngo\u00e0i ra, c\u00e1c tri\u1ec7u ch\u1ee9ng gi\u00e3n m\u1ea1ch \u1edf m\u0169i c\u0169ng nh\u01b0 c\u00e1c d\u1ea5u hi\u1ec7u gi\u00e3n m\u1ea1ch to\u00e0n th\u00e2n \u0111\u1ec1u kh\u00f4ng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong c\u1ea3 hai ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Quan h\u1ec7 h\u1ee3p t\u00e1c chi\u1ebfn l\u01b0\u1ee3c v\u1edbi SaNOtize<\/u><\/b><\/p>\n

V\u00e0o th\u00e1ng 7 n\u0103m 2021, Glenmark \u0111\u00e3 tham gia h\u1ee3p t\u00e1c chi\u1ebfn l\u01b0\u1ee3c d\u00e0i h\u1ea1n \u0111\u1ed9c quy\u1ec1n v\u1edbi c\u00f4ng ty c\u00f4ng ngh\u1ec7 sinh h\u1ecdc SaNOtize c\u1ee7a Canada<\/span>, \u0111\u1ec3 s\u1ea3n xu\u1ea5t, ti\u1ebfp th\u1ecb v\u00e0 ph\u00e2n ph\u1ed1i Thu\u1ed1c x\u1ecbt m\u0169i Nitric oxit \u0111\u1ed9t ph\u00e1 cho \u0111i\u1ec1u tr\u1ecb COVID-19 \u1edf \u1ea4n \u0110\u1ed9 v\u00e0 c\u00e1c th\u1ecb tr\u01b0\u1eddng ch\u00e2u \u00c1 kh\u00e1c bao g\u1ed3m Singapore<\/span>, Malaysia<\/span>, H\u1ed3ng K\u00f4ng, \u0110\u00e0i Loan, Nepal<\/span>, Brunei<\/span>, Cam-pu-chia, L\u00e0o, Myanmar<\/span>, Sri Lanka<\/span>, \u0110\u00f4ng Timor v\u00e0 Vi\u1ec7t Nam.<\/p>\n

Ph\u00ea duy\u1ec7t to\u00e0n c\u1ea7u cho NONS<\/u><\/b><\/p>\n

Glenmark ra m\u1eaft NONS d\u01b0\u1edbi t\u00ean th\u01b0\u01a1ng hi\u1ec7u FabiSpray\u00ae v\u00e0o th\u00e1ng 2 n\u0103m 2022, sau khi nh\u1eadn \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t s\u1ea3n xu\u1ea5t v\u00e0 ti\u1ebfp th\u1ecb t\u1eeb C\u01a1 quan Ki\u1ec3m so\u00e1t Thu\u1ed1c c\u1ee7a \u1ea4n \u0110\u1ed9 (DCGI) nh\u01b0 m\u1ed9t ph\u1ea7n c\u1ee7a quy tr\u00ecnh ph\u00ea duy\u1ec7t t\u0103ng t\u1ed1c. NONS \u0111\u00e3 nh\u1eadn \u0111\u01b0\u1ee3c d\u1ea5u CE \u1edf ch\u00e2u \u00c2u, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi vi\u1ec7c cho ph\u00e9p ti\u1ebfp th\u1ecb nh\u01b0 trong tr\u01b0\u1eddng h\u1ee3p c\u1ee7a Thi\u1ebft b\u1ecb Y t\u1ebf. Nh\u1edd d\u1ea5u CE n\u00e0y, SaNOtize \u0111\u01b0\u1ee3c ph\u00e9p ra m\u1eaft NONS t\u1ea1i Li\u00ean minh ch\u00e2u \u00c2u. NONS c\u0169ng \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn v\u00e0 \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Singapore<\/span>, H\u1ed3ng K\u00f4ng, Israel<\/span>, Th\u00e1i Lan, Indonesia<\/span> v\u00e0 Bahrain<\/span>, d\u01b0\u1edbi t\u00ean g\u1ecdi enovid\u2122 ho\u1eb7c VirX\u2122. Ngo\u00e0i \u1ea4n \u0110\u1ed9, NONS c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn tr\u00ean to\u00e0n c\u1ea7u \u0111\u1ec3 b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i vi-r\u00fat, bao g\u1ed3m SARS COV-2.<\/p>\n

Logo: https:\/\/saigonbiz.com.vn\/wp-content\/uploads\/2022\/07\/glenmark-pharmaceuticals-va-sanotize-thong-bao-bai-dang-da-duoc-binh-duyet-ve-thu-nghiem-lam-sang-giai-doan-3-tren-san-pham-xit-mui-oxit-nitric-moi-cua-sanotize-cho-covid-19-tren-tap-chi-lancet.jpg<\/a><\/p>\n<\/div>\n

ngu\u1ed3n: Glenmark Pharmaceuticals Ltd.<\/p>\n","protected":false},"excerpt":{"rendered":"

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